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Glutathione ensures smooth functioning of mitochondria by eradicating toxins and neutralising radicals

The phosphinic pseudotripeptide series of compounds designed from structural and mechanistic knowledge of IRAP and the related ERAP1 and ERAP2 are promising and some of them exert powerful IRAP inhibitory effects

To control that this basal activity is really mediated by MRP1, we mutated in MRP1 WT a cluster of 6 residues that were proven to be involved either in GSH binding or transport, R1138, R1142 38 , S1252, E1253 39 , or in binding of the GSH moiety of LTC 4 , R1249 and N1245 40

Second, GAMs also secrete matrix metallopeptidase 2 (MMP2) and MMP9, which are able to breakdown matrix proteins, such as collagen and fibronectin, thereby enabling glioma cells to penetrate and invade the surrounding stromal tissues (129)

Rossignol, Daniel A

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