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Despite robust evidence from preclinical studies demonstrating nicotines neuroprotective effects in animal PD models, recent transdermal nicotine trials in early-stage PD patients have failed to replicate these benefits

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doi: 10.1016/j.freeradbiomed.2023.03.027 18 ZhaoTYangQXiYXieZShenJLiZet al

Tojo, R., et al

XXVIII Brazilian Congress of Head and Neck Surgery

Notably, microbial imprinting in the respiratory epithelium may dynamically regulate future immune responses by modulating cytokine output such as IL-1b and IL-8 (149), resembling the trained immunity seen in macrophages