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Note: The use of binary terms such as male and female or men and women in this article reflects the language of the sources weve used

In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity

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Serious side effects are not reported and are rare, but patients must follow the care guidelines suggested by the professionals to get better results

For common, non-emergency causes, clinicians can provide prescriptions (for acid suppression, antibiotics when indicated, or short courses of steroids), order appropriate imaging or lab tests, and arrange referrals