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Furthermore, our findings suggested that inhibition of the p38 MAPK pathway is involved in the GHK-induced downregulation of mir-339-5p, and that the miR-339-5p/VEGFA axis plays a role in neuronal anti-apoptosis following ICH injury

Methodological caveat: Most human trials use combination formulations published studies often combine GHK-Cu with other actives (e.g., retinoids, vitamin C), making it difficult to isolate GHK-Cus independent contribution

Both have natural origins

Medical and Lifestyle Factors That Increase Bruising Risk Anticoagulant medications, including warfarin, dabigatran, and some antiplatelet agents, increase bleeding tendency at injection sites

These are preclinical findings, not human clinical proofs

It has also been investigated for its potential neuroprotective properties in CNS research models