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In the cardiovascular system, inflammation contributes to the development of atherosclerosis [29], while in the brain, it can lead to neuroinflammation, which is associated with cognitive decline and neurodegenerative diseases

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Lastly, HGH deficiency has adverse implications in other functions such as cardiac stroke volume, oxygen-carrying capacity, skeletal muscle strength, aerobic exercise capacity, vitality, vigor, blood pressure, and quality of life in general (Sattler, 2013)

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