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The FACS profile demonstrates the constitutive activity of HGPRBMY14 in the Cho-NFAT/CRE line as evidenced by the significant population of cells with blue fluorescent emission at 447 nm (see FIG

BioMed Pharmacother (2022) 148:112765

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Since NRF2 activation induces the antioxidant and detoxifying response to restore redox homeostasis state, in recent years there has been a growing interest in identifying and evaluating new compounds capable of targeting the KEAP1-NRF2 system, to induce cytoprotective response against OS

Dynamic modifications included methionine oxidation and both NEM and d5-NEM modifications on cysteine residues

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