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[3] Additionally, cyanocobalamin (vitamin B) in the Lipo-B injection may help boost energy production and may support a higher metabolic rate, which can further aid in burning calories and fat

Patients using compounded tirzepatide with B12 should monitor closely for signs of infection at injection sites, including increasing redness, warmth, swelling, pain, or purulent drainage, which may indicate contaminated product

If you are increasing your dose every four weeks as per the standard schedule and experiencing severe nausea each time, ask your prescriber about extending the time at each dose to six or eight weeks

PMID 19321896

Bhargava says

GLP-1 agonists alone often lead to some lean mass loss if protein and training are insufficient