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Glutathione S-transferases (GSTs) are a multifunctional enzyme family present across diverse organisms, playing a critical role in cellular detoxification

Further studies revealed that XFBD inhibits acute inflammatory responses by downregulating the IL-6/STAT3 pathway, controlling macrophage activity, and reducing inflammatory cytokine production

Methemoglobin cannot bind oxygen to deliver it to the body, thus methemoglobinemia leads to tissue hypoxia

The intestine therefore plays a central role in regulating and maintaining normal riboflavin body homeostasis

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