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Additionally, studies suggest the drugs cardiovascular risks are likely to be low, especially in young, otherwise healthy people and especially in comparison to cigarettes, says Foulds

For many years, a critical level of ten pack-years or more was associated with significant risk of developing a lung condition called COPD (chronic obstructive pulmonary disease), which ranges in severity and can lead to distressing symptoms including persistent coughing, wheezing and shortness of breath

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That is to say that one person may test negative within the detection window even if they used the drug simply because they processed it faster or their dose was small, for example

J Clin Endocrinol Metab 85 , 24022410 (2000)