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The FDA chose nine images from the first proposed 36 after reviewing the related scientific literature, analyzing the results from an 18,000-person study and taking into account more than 1,700 comments from many groups, including the tobacco industry, retailers, health professionals, public health and other advocacy groups, academics, state and local public health agencies, medical organizations and individual consumers

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Furthermore, linear regression models were employed to examine the temporal trends of disease burden from 1990 to 2021