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For each study, the relative risk was estimated for smoking one, five, or 20 cigarettes per day by using regression modelling between risk and cigarette consumption

[174] The FDA also sent an official request for information directly to JUUL Labs, requiring the company to submit important documents to better understand the reportedly high rates of youth use and the particular youth appeal of these products

A study by the University of California at San Diego and Truth Initiative found that it may have been effective in encouraging young girls to start smoking, with teen girls citing it as a favorite cigarette campaign