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Three reasons: Bulk packaging savings : one outer box vs 10 individual single-pack wrappers Lower retailer per-stick margin : bigger sale per transaction, lower percentage markup Loyal-buyer pricing : cartons are how regular smokers buy Per-stick savings on a carton typically run 5-12% vs 10 single packs

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Two low signal clusters of the immune cell dataset with a high ribosomal gene signature and/or low UMI count as well as clusters representing cell multiplets were excluded to ensure subsequent analysis on high-quality cells ( Supplementary Figure S1B )

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This requirement seems to appear in many cities and states because, according to several studies, pharmacies that do not sell tobacco products (including e-cigarettes) see fewer health disparities within their communities