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Extracellular sources of free radicals include UV light, ionizing radiation, smoking, heavy consumption of alcohol, unhealthy food, and some drugs

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Springer, Boston Roggenkamp D, Kpnick S, Stb F, Wenck H, Schmelz M, Neufang G (2013) Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model

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Reliable data are only available for the strongest consumer of ATP in astrocytes, the Na + -K + -ATPase [31], which was discussed to consume between 20% and 50% of the continuously regenerated ATP [65, 125], consistent with the important function of Na + -K + -ATPase in actively buffering extracellular K + that is released by neurons during neurotransmission in brain [9, 30]