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There have been reports of hypersensitivity reactions, including angioedema [see Warnings and Precautions (5.7)]

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"We try to study as much as we can, but it's difficult because as soon as we publish our results, this product we've been analysing has either been modified or is no longer on the market," he says

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[8] Begley, Sharon, "The Brain: The Origins of Dependence," Newsweek, February 12, 2001