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Lichodziejewska B, Kurnicka K, Grudzka K, et al

Immediate Effects Timeline The first few hours after combining these substances often produce the most noticeable interactions: 0-30 minutes (smoking/vaping) : Enhanced relaxation or increased sedation beyond what youd expect from cannabis alone 1-2 hours : Potential mood fluctuations as both substances reach peak activity in overlapping brain regions 2-4 hours : Extended duration of cannabis effects, particularly for mood and cognitive impacts 4-6 hours : Possible rebound anxiety or mood changes as cannabis effects fade while Prozac remains active Safety Risks and Side Effects Combining Prozac and cannabis creates several categories of risk that you should understand before using both substances

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Coronary spasm, a pathogenic trigger of vulnerable plaque rupture