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moderate certainty), but may result in little to no harm from other adverse events, such as hiccups, gastrointestinal disturbances, skin irritation from patches, throat irritation, or runny nose.43 Varenicline results in small harms from increases in nausea (32 RCTs, n = 14 963

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Regression analyses were performed to determine the relative contribution of smoking and other demographic variables (e.g., age, years of education, baseline BMI and onset age) to explain the variance in negative symptom improvement