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Large doses and long term usage can result in higher tolerance levels and dependence

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"Even if applications are submitted for only a portion of those products, the likelihood of FDA reviewing all of these applications during the one-year review period is low, given that this would be an unprecedented number of applications and several orders of magnitude greater than anything the Agency has experienced." It is not surprising that many vaping companies have chosen to give up rather than invest time, money, and effort in a process that might (or might not) give them a one-year reprieve and might (or might not) keep them in business longer than that