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21 Furthermore, in individuals with multiple sclerosis who smoke, there is an increased frequency of GPR15 + CD4 + T cells exhibiting Th17-like characteristics, implicating GPR15 as a potential link between environmental exposure and autoimmune pathogenesis

He told me about the cultural significance, how it helped him make friends, and he only smoked one cigarette a few days a week anyway

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Clinical testing of the cardiovascular effects of e-cigarette substitution for smoking: a living systematic review Rosa La, Robin Vernooij, Maria Qureshi, Riccardo Polosa, Rene OLeary Internal and Emergency Medicine 2