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It is still controversial, however, whether cannabis legalisation will reduce tobacco consumption, as nicotine is a highly addictive drug and most adolescents have an early exposure to cigarettes rather than marijuana [12]

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This further serves to uniquely center North Carolina at the heart of the continued global policy debate on tobacco related health concerns

However, different authors have used other statistical methods in studies related to our subject of our interest, and only some of these consider data about confounding factors

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