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These moonlighting activities encompass non-metabolic functions distinct from their canonical catalytic roles, often arising from dynamic changes in post-translational modifications, ligand binding, redox state, or oligomerization that induce conformational or subcellular localization shifts

Additionally, oxidative stress plays a significant role, as reflected by elevated markers of oxidized lipids and reactive oxygen species (ROS) in the synovial fluid and serum of IPOA patients

VDAC1 and IP3R mainly act as transmembrane signaling channels, indirectly modulating the threshold for autophagy activation by regulating membrane lipid exchange, ATP permeability, and cellular metabolism [98,99,100]

Individuals with confirmed B12 deficiency due to dietary insufficiency may benefit from oral B12 supplementation (including sublingual forms)

However, no extensive studies confirm this practice as effective

Effects of the diuretic furosemide on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat