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As it relates to toxicology, it refers to the interaction of two or more agents so that their combined effect is greater than the sum of their individual effects

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A third of teens said they chose e-cigarettes because of the fruit and candy flavors available, while others said they opted for e-cigarettes because they believed they are less harmful than cigarettes, according to the National Youth Tobacco Study

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from The Regents of the University of California

Department of Health and Human Services) (2014b) The health consequences of smoking: 50 years of progress