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The present study was conducted under the Declaration of Helsinki, and followed the Ethics Committee of the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine

286 Specifically, MTF-1 triggers the expression of the Selenoprotein 1 ( Sepw1 ) gene, responsible for encoding an antioxidant GSH-binding protein that effectively scavenges free radicals

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The H-bond with Phe177 is critical in providing a fully functional active site.Fe +2 cofactor of the 5-LOX enzyme was bound to capsaicin and gingerol, which causes the chelation of these molecules