l carnitine vs berberine for weight loss Dihydroberberine: Results from the Latest Studies The Difference Between L-Carnitine &

(2019) Neutral sphingomyelinase modulation in the protective/preventive role of rMnSOD from radiation-induced damage in the brain, Int

Overexpression of p66shc impairs IGF-I-stimulated p52shc tyrosine phosphorylation - NaCl - activity against phosphotyrosine, optimal at 0.1 M phorbol 12-myristate 13-acetate - enzyme gene is among the 10 genes with the largest increased in expression upon phorbol 12-myristate 13-acetate stimulation spermidine - activation spermine sulfhydryl compounds - - suramin - 0.01 mM, about 30% increase in activity of isoforms PTPalpha, LAR tetrasodium 2-(((2-(3-(((3-(5-((2,5-disulfonatophenyl)carbamoyl)-1H-benzimidazol-2-yl)phenyl)carbamoyl)amino)phenyl)-1H-benzimidazol-5-yl)carbonyl)amino)benzene-1,4-disulfonate - 0.01 mM, up to 4.5 activation of isoform PTPalpha wild-type Triton X-100 - 0.1%, 25-30% activation UpA - uPA regulates SHP-2 phosphorylation, stimulates its catalytic activity and association with PDGFR-beta and with lipid rafts 15 - 19 3,6-fluorescein diphosphate 0.02 - 0.156 4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate 0.08 - 148 4-nitrophenyl phosphate 0.0039 - 0.0795 6,8-difluoro-4-methylumbelliferyl phosphate 2.6 AAAAApYRHRR - pH 7.4, temperature not specified in the publication, RPTPalpha 0.0228 - 0.219 acetyl-DADEpY-NH2 1.1 - 97.5 acetyl-DADEpYL-NH2 0.034 ADEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.058 AKFEDTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.49 ARKRIpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.075 AVWEFpYpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.022 AWSpYADpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.091 AYTEpYTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 37 bis(4-nitrophenyl) phosphate pH 7.3, 22C, recombinant enzyme 0.00011 - 0.00026 bovine serum albumin - 0.0005 Cdk2-pTpY/CycA - in 50 mM Tris, 50 mM Bis-Tris, 100 mM Na acetate, pH 6.0-6.5, at 5-25C - 0.00035 - 0.1 DADEpYLIPQQG 0.028 DAEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.013 DDT-(3,5-difluoro)YDpYAA - pH 7.4 0.014 DDTYDpYAA - pH 7.4 0.023 DFEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 5.2 - 11.1 difluoromethylumbelliferyl phosphate 0.0036 DNL-(3,5-difluoro)YpYWD - pH 7.4 0.0058 DNLYpYWD - pH 7.4 0.017 DWEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 1.4 EADTApYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.027 - 0.054 EIFDFpYAA 0.031 FDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.013 - 0.039 FDIDIpYAA 0.015 fluorescein diphosphate - 22C, pH 5.5 0.028 - 0.066 FYDIDpYAA 0.175 GESDGGpYMDMSKD - - 0.0096 - 0.0191 GNGDpYMPMSPKS 0.0029 insulin receptor phosphopeptide - isoform PTP1B, 37C, pH 6.9 - 0.77 LIEDNEpYTARQGA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.00028 - 0.012 lysozyme - 0.00014 - 0.0126 myelin basic protein - 0.0024 - 10 p-nitrophenyl phosphate 0.127 PGSAAP-pY-LKTKFI pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a STAT3 peptide 1.6 - 8.5 phosphotyrosine 0.015 phosphotyrosyl bovine serum albumin - - - 0.059 - 0.789 platelet-derived growth factor receptor value varies with the point of tyrosine phosphorylation, values for truncated enzyme reduced relative to wild-type form - 0.119 PQDKEY-pY-KVKEPG pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a JAK2 peptide 0.014 RE-(3,5-difluoro)YEFpYAA - pH 7.4 0.006 REYEFpYAA - pH 7.4 0.124 RKGSGD-pY-MPMSPK pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a IRS1 peptide 1.2 RRISTpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.048 - 0.18 SASASpYDWEF 0.53 - 2.3 SASASpYSASA 1.07 TATEPQpYQPGEN - pH 7.4, temperature not specified in the publication, RPTPalpha 0.33 TGFLTELpYVATRWY - - 0.142 - 1.16 TSTEPQpYQPGENL 0.045 - 0.068 WAGDDpYAA 0.043 WDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.0032 - 0.0063 WDEDFpYDWEF 0.15 - 0.21 WDEDFpYRWKF 0.046 - 0.053 WDEDFpYSASA 0.56 - 0.78 WRKRFpYDWEF 0.0215 [Eps15 peptide846-854 P850V]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - 0.0438 [Eps15 peptide846-854]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - additional information additional information - 2 - 71.6 4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate 0.01 - 27.5 4-nitrophenyl phosphate 0.00016 - 8.66 6,8-difluoro-4-methylumbelliferyl phosphate 30 AAAAApYRHRR - pH 7.4, temperature not specified in the publication, RPTPalpha 2 - 8 ADEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 19 AKFEDTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 39 ARKRIpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 24 AVWEFpYpYAA - pH 7.4, temperature not specified in the publication, SHP-1 13 AWSpYADpYAA - pH 7.4, temperature not specified in the publication, SHP-1 17 AYTEpYTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.033 bis(4-nitrophenyl) phosphate pH 7.3, 22C, recombinant enzyme 30 DAEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 3 - 6 DDT-(3,5-difluoro)YDpYAA - pH 7.4 33 DDTYDpYAA - pH 7.4 37 DFEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 3 - 6 DNL-(3,5-difluoro)YpYWD - pH 7.4 32 DNLYpYWD - pH 7.4 30 DWEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 26 EADTApYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 26 - 32 EIFDFpYAA 30 FDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 30 - 33 FDIDIpYAA 50 - 66 FYDIDpYAA 200 GESDGGpYMDMSKD - - 7.7 - 18.4 GNGDpYMPMSPKS 61.5 insulin receptor phosphopeptide - isoform PTP1B, 37C, pH 6.9 - 8.3 LIEDNEpYTARQGA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.37 - 3.1 p-nitrophenyl phosphate 3.6 PGSAAP-pY-LKTKFI pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a STAT3 peptide 0.66 - 7.2 platelet-derived growth factor receptor value varies with the point ot tyrosine phosphorylation, values for truncated enzyme increased relative to wild-type form - 3.1 PQDKEY-pY-KVKEPG pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a JAK2 peptide 44 RE-(3,5-difluoro)YEFpYAA - pH 7.4 33 REYEFpYAA - pH 7.4 3.2 RKGSGD-pY-MPMSPK pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a IRS1 peptide 49 RRISTpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 12 - 35 SASASpYDWEF 23 - 42 SASASpYSASA 9.7 TATEPQpYQPGEN - pH 7.4, temperature not specified in the publication, RPTPalpha 177 TGFLTELpYVATRWY - - 8.9 - 258 TSTEPQpYQPGENL 3 - 57 WAGDDpYAA 48 WDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 43 - 75 WDEDFpYDWEF 42 - 73 WDEDFpYRWKF 37 - 50 WDEDFpYSASA 1.3 - 1.7 WRKRFpYDWEF 13.4 [Eps15 peptide846-854 P850V]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - 17.3 [Eps15 peptide846-854]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - 0.024 - 18 4-nitrophenyl phosphate 39 AAAAApYEEVH - pH 7.4, temperature not specified in the publication, RPTPalpha 12 AAAAApYRHRR - pH 7.4, temperature not specified in the publication, RPTPalpha 0.00005 Ac-AAAApYAAAA-NH2 - pH 7.0, 25C 0.0016 Ac-AAAEpYAAAA-NH2 - pH 7.0, 25C 0.0003 Ac-AAAQpYAAAA-NH2 - pH 7.0, 25C 0.04 Ac-DGEEpYDDPF-NH2 - pH 7.0, 25C 0.0062 Ac-ENDEpYTARE-NH2 - pH 7.0, 25C 0.0006 Ac-TEPQpYQPGE-NH2 - pH 7.0, 25C 0.046 Ac-YGEEpYDDLY-NH2 - pH 7.0, 25C 0.021 Ac-YGYEpYDDEY-NH2 - pH 7.0, 25C 0.82 ADEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.34 AKFEDTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 81 ARKRIpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 13 ASSDDpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 3.3 AVWEFpYpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.58 AWSpYADpYAA - pH 7.4, temperature not specified in the publication, SHP-1 1.9 AYTEpYTpYAA - pH 7.4, temperature not specified in the publication, SHP-1 0.0009 bis(4-nitrophenyl) phosphate pH 7.3, 22C, recombinant enzyme 1.1 DAEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 1.6 DFEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 1.7 DWEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 19 EADTApYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.48 - 1.2 EIFDFpYAA 0.00112 - 0.00269 ENPE(pY)LGLD 0.00115 - 0.00271 ENPE(pY)LTPQ 1 FDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 0.77 - 2.5 FDIDIpYAA 0.00187 - 0.00397 FDNL(pY)2WDQD 0.75 - 2.4 FYDIDpYAA 11 LIEDNEpYTARQGA - pH 7.4, temperature not specified in the publication, RPTPalpha 28.35 PGSAAP-pY-LKTKFI pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a STAT3 peptide 0.00052 - 0.00142 PLQR(pY)SEDP 26.05 PQDKEY-pY-KVKEPG pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a JAK2 peptide 25.81 RKGSGD-pY-MPMSPK pH 6.4, 25C, recombinant PTPepsilon D1 domain, substrate is a IRS1 peptide 41 RRISTpYAA - pH 7.4, temperature not specified in the publication, RPTPalpha 0.19 - 0.25 SASASpYDWEF 0.013 - 43 SASASpYSASA 9.1 TATEPQpYQPGEN - pH 7.4, temperature not specified in the publication, RPTPalpha 7.7 TSTEPQpYQPGENL - pH 7.4, temperature not specified in the publication, RPTPalpha 0.53 - 1.3 WAGDDpYAA 1.1 WDEDFpYAA - pH 7.4, temperature not specified in the publication, SHP-2 6.8 - 23 WDEDFpYDWEF 0.28 - 0.34 WDEDFpYRWKF 0.7 - 69 WDEDFpYSASA 0.0022 - 0.0023 WRKRFpYDWEF 623.3 [Eps15 peptide846-854 P850V]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - 395 [Eps15 peptide846-854]-tyrosine phosphate recombinant wild-type enzyme, pH and temperature not specified in the publication - 0.0068 (2E)-1-(3-aminophenyl)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0062 (2E)-1-(4-aminophenyl)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0029 (2E)-1-[3-(benzyloxy)phenyl]-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0026 (2E)-3-(5-bromo-2,4-dihydroxyphenyl)-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0111 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(3-methoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0113 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(3-[[(methoxycarbonyl)sulfanyl]amino]phenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0042 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-butoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0137 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0099 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0139 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-(dimethylamino)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0068 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-(piperidin-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0035 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.007 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(3-methylbut-3-en-2-yl)-4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0264 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(dimethylamino)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0049 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(piperidin-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0045 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.006 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(1H-pyrazol-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.03 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0184 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.008 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(morpholin-4-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0026 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(piperidin-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0044 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0053 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0044 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0029 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0019 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0053 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(prop-2-en-1-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0035 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0027 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(4-methylphenyl)sulfonyl]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0034 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0063 (2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[6-(dimethylamino)-1,3-benzodioxol-5-yl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0029 (2E)-3-[5-bromo-2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.0103 (2E)-3-[5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[4-hydroxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one - pH not specified in the publication, temperature not specified in the publication 0.023 - 0.1 (5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.0003 - 0.113 (5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.01 16alphaH,17-isovaleryloxy-ent-kauran-19-oic acid - pH 6.0, 30C 0.019 - 0.109 2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.00091 - 0.115 2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.00061 - 0.147 2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.00019 - 0.0038 2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 0.00017 - 0.088 2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid 2 - 81 2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid 0.0042 2-[6-chloro-5-(1-naphthalyloxy)-1H-benzimidazol-2-yl]thio-N-(thiazol-2-yl)acetamide pH 7.0, 37C 2.5 3-(1-carboxy-ethoxy)-6-chloro-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.052 3-(carboxy-fluoro-methoxy)-6-chloro-benzo(b)thiophene-2-carboxylic acid - pH 7.0, 22C 0.86 3-(carboxymethoxy)-2-naphthoic acid - pH 7.0, 22C 0.00092 3-(carboxymethoxy)-5-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.0017 3-(carboxymethoxy)-5-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.01 3-(carboxymethoxy)-5-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.0016 3-(carboxymethoxy)-6-((1-(ethylsulfonyl)-piperidin-4-yl)amino)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid - pH 7.0, 22C 0.00068 3-(carboxymethoxy)-6-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.00074 3-(carboxymethoxy)-6-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.0024 3-(carboxymethoxy)-6-(tetrahydro-2H-pyran-4-ylamino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.035 3-(carboxymethoxy)-6-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 2.5 3-(carboxymethoxy)-6-methylthieno(3,2-c)pyridine-2-carboxylic acid - pH 7.0, 22C 0.16 3-(carboxymethoxy)benzo(b)thiophene-2-carboxylic acid - pH 7.0, 22C 2.5 3-(carboxymethoxy)furo(2,3-b)pyridine-2-carboxylic acid - pH 7.0, 22C 0.2 - 0.23 3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid 0.0092 3-(carboxymethoxy)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid - pH 7.0, 22C 0.077 3-(carboxymethoxy)thieno(3,2-b)pyridine-2-carboxylic acid - pH 7.0, 22C 0.28 3-(carboxymethoxy)thieno(3,2-b)thiophene-2-carboxylic acid - pH 7.0, 22C 0.026 3-carboxymethoxy-6-(4-hydroxyphenyl)-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.02 3-carboxymethoxy-6-(5-methyl-1-phenyl-1H-pyrazol-3-ylcarbamoyl)-benzo(b)thiophene-2-carboxylic acid - pH 7.0, 22C 0.061 3-carboxymethoxy-6-chloro-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.128 3-carboxymethoxy-6-phenylbenzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.03 3-carboxymethoxy-6-thiophen-2-yl-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.119 3-carboxymethoxy-7-chloro-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.037 3-carboxymethoxy-7-methyl-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.011 3-carboxymethoxy-naphtho(1,2-b)thiophene-2-carboxylic acid - pH 7.0, 22C 0.5 3-carboxymethoxy-thieno(3,2-c)quinoline-2-carboxylic acid - pH 7.0, 22C 0.0216 3-[2,5-dimethyl-3-[(3-oxo-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl)methyl]-1H-pyrrol-1-yl]benzoic acid pH 7.0, 25C 0.000026 4-(difluoro(phosphono)methyl)-N-pentadecanoyl-L-phenylalanyl-L-a-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide - - 0.0023 4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl 4-bromobenzoate - pH not specified in the publication, temperature not specified in the publication 0.0024 4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl 4-tert-butylbenzoate - pH not specified in the publication, temperature not specified in the publication 0.0049 4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl benzoate - pH not specified in the publication, temperature not specified in the publication 0.03 4-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]butanoic acid - pH not specified in the publication, temperature not specified in the publication 0.0052 5-chloro-N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-1-methyl-2-(methylthio)-1H-benz-imidazole-6-carboxamide pH 7.0, 37C 0.00037 6-((1-(benzylsulfonyl)piperidin-4-yl)amino)-3-(carboxymethoxy)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - pH 7.0, 22C 0.042 6-bromo-3-carboxymethoxy-benzo(b)-thiophene-2-carboxylic acid - pH 7.0, 22C 0.00023 acrolein - in sodium acetate (100 mM), bis-Tris (50 mM), Tris (50 mM), diethylenetriaminepentaacetic acid (5 mM), and 2,5-dimethylfuran (5% v/v), at pH 7 and 25C 0.00001 aquastatin A - - 0.00014 - 0.0148 bis(2-ethyl-maltolato)oxidovanadium(IV) 0.0382 bis(3-hydroxy-2-methyl-4(1H)pyridinonato)oxidovanadium(IV) pH 5.0, 22C, recombinant enzyme, versus 4-nitrophenyl phosphate 0.00016 - 0.0065 bis(acetylacetonato)oxidovanadium(IV) 0.0108 ethyl 4-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]butanoate - pH not specified in the publication, temperature not specified in the publication 0.0152 ethyl [4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]acetate - pH not specified in the publication, temperature not specified in the publication 0.000017 - 0.00037 fluorescein arsenical hairpin binder - 0.006 - 0.196 H2O2 0.2951 hesperetin pH 6.0, 37C 0.0816 hesperetin 5-O-glucoside pH 6.0, 37C - 0.0502 hesperidin pH 6.0, 37C 0.0118 lupenone - pH 6.0, 37C 0.0034 lupeol - pH 6.0, 37C 0.0000024 N-((4-(difluoro(phosphono)methyl)phenyl)acetyl)-L-alpha-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide - - 0.0034 N-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl]-4-tert-butylbenzamide - pH not specified in the publication, temperature not specified in the publication 0.0413 N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-2,2,2-trifluoroacetamide pH 7.0, 37C 0.1543 neohesperidin pH 6.0, 37C 0.0003 - 0.0007 orthovanadate 0.00073 - 0.0107 phenylhydrazonopyrazolone sulfonate 1 0.017 PO43- - active site-directed inhibitor 0.0053 - 0.0057 suramin 0.002 - 0.0031 ursolic acid 0.0000056 Zn2+ at pH 7.4 and 25C 0.03 [4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]acetic acid - pH not specified in the publication, temperature not specified in the publication additional information additional information - 0.00927 (1R,3aS,3bS,10aR,10bS,12aR)-1-[(2R)-4-carboxybutan-2-yl]-6,6,10a,12a-tetramethyl-1,2,3,3a,3b,4,6,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-9-carboxylic acid Homo sapiens - pH and temperature not specified in the publication 0.01433 (2alpha,3alpha)-2,3-dihydroxyolean-12-en-28-oic acid Homo sapiens - PTPB1 0.00493 (2beta,3beta)-2,3-dihydroxyolean-12-en-28-oic acid Homo sapiens - PTPB1 0.05 (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - above, pH 6.0, 37C 0.05 (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - above, pH 6.0, 37C 0.0183 (2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.0198 (2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.0309 (2E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.0191 (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.0117 (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.0207 (2E)-3-[4-hydroxy-2-methoxy-5-(3-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens - pH 6.0, 37C 0.00017 (2R)-2-benzyl-3-[2,6-dibromo-4-(6-bromo-5a,11a-dihydrobenzo[b]naphtho[2,3-d]furan-11-yl)phenyl]propanoic acid Homo sapiens - 0.0632 (2Z)-2-([5-[4-(1H-tetrazol-1-yl)phenyl]furan-2-yl]methylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Homo sapiens pH 7.0, 25C 0.3 (2Z)-2-[[5-(2-methyl-5-nitrophenyl)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Homo sapiens above, pH 7.0, 25C 0.0083 (3alpha,5beta,8alpha,9beta,10alpha,13alpha)-3-[[(2E)-4-phenylbut-2-enoyl]oxy]kaur-16-en-18-oic acid Homo sapiens pH 6.0, 37C 0.00479 (3beta)-3-(acetyloxy)olean-12-en-28-oic acid Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.00534 (3beta)-3-hydroxyolean-12-en-28-oic acid Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.0064 (3beta)-3-hydroxyoleana-11,13(18)-dien-28-oic acid Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.03 (4aR,6aR,6bS,8aR,12aS,14aR,14bR)-8a-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,4a,5,6,6a,6b,7,8a,9,10,11,12,12a,14,14a,14b-hexadecahydropicene-3,8(2H,4H)-dione Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.00377 (4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-4a,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-5(1H)-one Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.00148 - 0.00493 (4aS,6aS,6bR,13aR)-10-acetyl-2,2,6a,6b,9,9,13a-heptamethyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.00175 - 0.00566 (4aS,6aS,6bR,13aR)-10-hexanoyl-2,2,6a,6b,9,9,13a-heptamethyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.00192 - 0.00644 (4aS,6aS,6bR,13aR)-11-amino-2,2,6a,6b,9,9,13a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,13,13a,13b,14,15b-hexadecahydropiceno[3,2-d][1,3]thiazole-4a(2H)-carboxylic acid 0.00165 - 0.00599 (4aS,6aS,6bR,13aR)-2,2,6a,6b,9,9,13a-heptamethyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.0026 - 0.00844 (4aS,6aS,6bR,13aR)-2,2,6a,6b,9,9,13a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,13,13a,13b,14,15b-hexadecahydropiceno[2,3-d][1,2]oxazole-4a(2H)-carboxylic acid 0.00064 - 0.00439 (4aS,6aS,6bR,13aR)-2,2,6a,6b,9,9,13a-heptamethyl-10-(pyridin-3-ylcarbonyl)-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.00081 - 0.00362 (4aS,6aS,6bR,13aR)-2,2,6a,6b,9,9,13a-heptamethyl-10-(pyridin-4-ylcarbonyl)-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.00139 - 0.0038 (4aS,6aS,6bR,13aR)-2,2,6a,6b,9,9,13a-heptamethyl-10-phenyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,13,13a,13b,14,15b-octadecahydro-4aH-chryseno[1,2-f]indazole-4a-carboxylic acid 0.00178 - 0.00551 (4aS,6aS,6bR,14aR)-11-amino-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinazoline-4a(2H)-carboxylic acid 0.00261 - 0.0065 (4aS,6aS,6bR,14aR)-2,2,6a,6b,9,9,11,14a-octamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinazoline-4a(2H)-carboxylic acid 0.00273 - 0.00819 (4aS,6aS,6bR,14aR)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinazoline-4a(2H)-carboxylic acid 0.00179 - 0.00831 (4aS,6aS,6bR,14aR)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinoxaline-4a(2H)-carboxylic acid 0.00544 (4aS,6aS,6bR,14aR)-2,2,6a,6b,9,9,14a-heptamethyl-11-(methylamino)-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinazoline-4a(2H)-carboxylic acid Homo sapiens - PTPB1 0.00061 - 0.0016 (4aS,6aS,6bR,15aR)-2,2,6a,6b,9,9,15a-heptamethyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,15,15a,15b,16,17b-octadecahydro-4aH-chryseno[2,1-b]carbazole-4a-carboxylic acid 0.00143 - 0.00588 (4aS,6aS,6bR,16aR)-2,2,6a,6b,9,9,16a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,16,16a,16b,17,18b-hexadecahydrochryseno[1,2-b]phenazine-4a(2H)-carboxylic acid 0.00411 (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-1,2,3,3a,3b,4,6,6a,7,9a,10,10a,10b,11,12,12a-hexadecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.03944 (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-2,3,3a,3b,4,6,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[2,3-d][1,2,3]thiadiazol-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00913 (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-2,3,3a,3b,4,6,6a,9a,10,10a,10b,11,12,12a-tetradecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d][1,2]oxazol-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00162 (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,4,6,6a,7,9a,10,10a,10b,11,12,12a-hexadecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00557 (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-8-amino-6,6,10a,12a-tetramethyl-2,3,3a,3b,4,6,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[2,3-d][1,3]thiazol-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.01165 (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00862 (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinoxalin-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00911 (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-6,6,8,11a,13a-pentamethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.00361 (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-8-amino-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoic acid Homo sapiens - pH and temperature not specified in the publication 0.028 (5beta,8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-oic acid Homo sapiens pH 6.0, 37C 0.0066 (5Z)-3-benzyl-5-(5-bromo-4-butoxy-2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-3-benzyl-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0072 (5Z)-3-benzyl-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0206 (5Z)-3-butyl-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0096 (5Z)-3-butyl-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0298 (5Z)-5-(4-hydroxy-2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0142 (5Z)-5-(5-bromo-2,4-dimethoxybenzylidene)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0082 (5Z)-5-(5-bromo-2,4-dimethoxybenzylidene)-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0121 (5Z)-5-(5-bromo-2,4-dimethoxybenzylidene)-3-butyl-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0223 (5Z)-5-(5-bromo-2,4-dimethoxybenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0049 (5Z)-5-(5-bromo-4-butoxy-2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0123 (5Z)-5-(5-bromo-4-butoxy-2-methoxybenzylidene)-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-(5-bromo-4-butoxy-2-methoxybenzylidene)-3-butyl-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0113 (5Z)-5-(5-bromo-4-hydroxy-2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0122 (5Z)-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0227 (5Z)-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-3-(3-methylbut-2-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-3-(propan-2-yl)-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-[2-methoxy-5-(prop-2-en-1-yl)-4-(tetrahydro-2H-pyran-2-yloxy)benzylidene]-3-methyl-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0076 (5Z)-5-[4-(benzyloxy)-5-bromo-2-methoxybenzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0103 (5Z)-5-[4-(benzyloxy)-5-bromo-2-methoxybenzylidene]-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0081 (5Z)-5-[4-(benzyloxy)-5-bromo-2-methoxybenzylidene]-3-methyl-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0293 (5Z)-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.012 (5Z)-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-3-(3-methylbut-2-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0064 (5Z)-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-3-(propan-2-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.03 (5Z)-5-[4-hydroxy-2-methoxy-5-(prop-2-en-1-yl)benzylidene]-3-methyl-1,3-thiazolidine-2,4-dione Homo sapiens IC50 above 0.03 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0081 (5Z)-5-[5-bromo-2-methoxy-4-(prop-2-en-1-yloxy)benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.017 (5Z)-5-[5-bromo-2-methoxy-4-(prop-2-en-1-yloxy)benzylidene]-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0079 (5Z)-5-[5-bromo-2-methoxy-4-(prop-2-en-1-yloxy)benzylidene]-3-butyl-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0046 (5Z)-5-[5-bromo-2-methoxy-4-(propan-2-yloxy)benzylidene]-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0097 (5Z)-5-[5-bromo-2-methoxy-4-(propan-2-yloxy)benzylidene]-3-butyl-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.0053 (5Z)-5-[5-bromo-2-methoxy-4-[(3-methylbut-2-en-1-yl)oxy]benzylidene]-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.01 (5Z)-5-[5-bromo-2-methoxy-4-[(4-methylpent-3-en-1-yl)oxy]benzylidene]-3-(4-methylpent-3-en-1-yl)-1,3-thiazolidine-2,4-dione Homo sapiens in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol, at 37C 0.00466 (6aS,6bR,8aR,10S,12aS,12bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydropicen-5(1H)-one Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.0063 (E)-1-[4-(1H-pyrazol-1-yl)phenyl]-3-(5-allyl-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0126 (E)-2-[4-[3-[5-allyl-2-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]acryloyl]phenoxy]acetic acid Homo sapiens pH 6.0, 37C 0.0069 (E)-3-(5-allyl-4-hydroxy-2-isopropoxyphenyl)-1-[3-(dimethylamino)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0248 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0109 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(3-allyl-4-methoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0146 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(3-methoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0053 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(4-ethoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0129 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0074 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0123 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-(4-morpholinophenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0163 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[2-(dimethylamino)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0095 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[2-(piperidin-1-yl)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.003 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[2-methoxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0047 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[3-(diallylamino)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.00057 - 0.005 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[3-(dimethylamino)phenyl]prop-2-en-1-one 0.0072 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[3-(piperidin-1-yl)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0065 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(allyloxy)-2-hydroxyphenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0039 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(allyloxy)-2-methoxyphenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0054 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(allyloxy)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0059 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(diallylamino)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0069 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0069 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-(piperidin-1-yl)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0082 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0054 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0059 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0118 (E)-3-(5-allyl-4-hydroxy-2-methoxyphenyl)-1-[6-(dimethylamino)benzo[d][1,3]dioxol-5-yl]prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.0094 (E)-3-[5-allyl-2-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Homo sapiens pH 6.0, 37C 0.005 (E)-4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenyl-4-(tert-butyl)benzoate Homo sapiens pH 6.0, 37C 0.0066 (E)-4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenyl-4-bromobenzoate Homo sapiens pH 6.0, 37C 0.0046 (E)-4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenylbenzoate Homo sapiens pH 6.0, 37C 0.0328 (E)-4-[4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenoxy]butanoic acid Homo sapiens pH 6.0, 37C 0.0058 (E)-5-[4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenoxy]pentanoic acid Homo sapiens pH 6.0, 37C 0.0094 (E)-ethyl 2-[4-[3-(5-allyl-hydroxy-2-methoxyphenyl)acryloyl]phenoxy]acetate Homo sapiens pH 6.0, 37C 0.0039 (E)-ethyl 5-[4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenoxy]pentanoate Homo sapiens pH 6.0, 37C 0.02526 (E)-ethyl4-[4-[3-(5-allyl-4-hydroxy-2-methoxyphenyl)acryloyl]phenoxy]butanoate Homo sapiens pH 6.0, 37C 0.022 (E)-N-(4,5-diphenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamide Homo sapiens - 0.021 (E)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]-2-(3,4-dichlorophenyl)ethenesulfonamide Homo sapiens - 0.0229 - 0.0324 (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0008 - 0.0154 (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid 0.0468 - 0.0967 (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid 0.0158 - 0.0724 (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid 0.0194 - 0.3 (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid 0.0052 - 0.0734 (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0055 - 0.0194 (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0048 - 0.1228 (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0038 - 0.0425 (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0106 - 0.0742 (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0014 - 0.0188 (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.001 - 0.0183 (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.005 - 0.0326 (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0074 - 0.0608 (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0083 - 0.0431 (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0059 - 0.0181 (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0063 - 0.0114 (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid 0.0013 - 0.0071 (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid 0.00834 (Z)-5-(2,3-dibromo-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.00086 (Z)-5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.01051 (Z)-5-(3-bromo-4,5-dihydroxybenzylidene)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.01277 (Z)-5-(4-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxyphenoxy)benzylidene)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.0028 1,1'-(piperazine-1,4-diyl)bis(4-(3-(dibenzylamino)phenyl)butane-1,2,4-trione) Homo sapiens - in 50 mM MOPS, pH 6.5, at 30C 0.2 1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)ethanone Homo sapiens - above 0.0079 1-heptyl-1H-imidazol-4-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.013 15-hydroxykaur-9(11),16-dien-19-oic acid Homo sapiens pH 6.0, 37C 0.0081 19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid Homo sapiens - - 0.00074 2',4'-dihydroxy-1,1'-biphenyl Homo sapiens pH 7.0, 37C, PTP-B1 0.00389 2,2'-[benzene-1,4-diylbis(methanediyloxybenzene-4,1-diyl)]bis(oxoacetic acid) Homo sapiens - pH and temperature not specified in the publication 0.001 2,5-dihydroxy-3-[7-(2-methylbenzyl)-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione Homo sapiens - 0.0056 2,5-dihydroxy-3-[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione Homo sapiens - 0.0041 2-(1-(2,4-dichlorobenzyl)-1H-imidazol-2-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0039 2-(1-(2,4-dichlorobenzyl)-1H-imidazol-4-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(2,4-dichlorobenzyl)-1H-imidazol-5-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0011 2-(1-(3-chlorobenzyl)-1H-imidazol-2-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.00063 2-(1-(3-chlorobenzyl)-1H-imidazol-4-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(3-chlorobenzyl)-1H-imidazol-5-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0031 2-(1-(4-chlorobenzyl)-1H-imidazol-4-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(4-chlorobenzyl)-1H-imidazol-5-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0057 2-(1-(4-fluorobenzyl)-1H-imidazol-2-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(4-fluorobenzyl)-1H-imidazol-4-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 2-(1-(4-fluorobenzyl)-1H-imidazol-5-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0082 2-(1-heptyl-1H-imidazol-2-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0125 2-(1-heptyl-1H-imidazol-5-yl)-7-hydroxy-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 - 0.0143 2-(4-hydroxyphenyl)-3-[(3,4-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0007 - 0.0057 2-(4-hydroxyphenyl)-3-[(4-carboxy-3-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.000076 2-[(4-[2-acetamido-3-[(5-[[(1S)-1-carboxy-3-(methylsulfanyl)propyl]amino]-5-oxopentyl)amino]-3-oxopropyl]-2-ethylphenyl)(oxalo)amino]benzoic acid Homo sapiens pH and temperature not specified in the publication 0.0084 2-[6-chloro-5-(1-naphthalyloxy)-1H-benzimidazol-2-yl]thio-N-(thiazol-2-yl)acetamide Homo sapiens pH 7.0, 37C 0.0128 24-hydroxyursolic acid Homo sapiens - - 0.00072 28-(10-decanoic)-oleanolic acid Homo sapiens - 0.00059 28-(12-dodecanoic)-oleanolic acid Homo sapiens - 0.0021 28-(2-acetic)-oleanolic acid Homo sapiens - 0.00133 28-(4-butyric)-oleanolic acid Homo sapiens - 0.00088 28-(6-hexanoic)-oleanolic acid Homo sapiens - 0.00078 28-(8-octanoic)-oleanolic acid Homo sapiens - 0.01544 28-(glycine)-oleanolic acid amide Homo sapiens - 0.01635 28-(L-glutamic acid)-oleanolic acid amide Homo sapiens - 0.00331 28-(L-phenylalanine)-oleanolic acid amide Homo sapiens - 0.00319 28-(p-carboxyphenyl)-oleanolic acid amide Homo sapiens - 0.00074 28-[4-butyric((R)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00059 28-[4-butyric((S)-1-carboxy-3-indole-ethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00462 28-[4-butyric((S)-1-carboxy-5-imidazole-ethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00055 28-[4-butyric((S)-1-carboxy-methylthioethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00057 28-[4-butyric((S)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00066 28-[4-butyric(1-carboxy-2,3-dimethoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00082 28-[4-butyric(1-carboxy-3,4-dimethoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00044 28-[4-butyric(1-carboxy-3,4-oxymethyleneoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00063 28-[4-butyric(1-carboxy-3,5-dimethoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00051 28-[4-butyric(1-carboxy-m-chlorophenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00052 28-[4-butyric(1-carboxy-m-methoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00056 28-[4-butyric(1-carboxy-o-chlorophenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00053 28-[4-butyric(1-carboxy-o-methoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00055 28-[4-butyric(1-carboxy-o-methylphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00061 28-[4-butyric(1-carboxy-p-chlorophenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00057 28-[4-butyric(1-carboxy-p-fluorophenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.0006 28-[4-butyric(1-carboxy-p-methoxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00065 28-[4-butyric(1-carboxy-p-methylphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00045 28-[4-butyric(1-carboxy-p-nitrophenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00593 2beta,3beta-2,3-dihydroxyolean-12-en-28-oic acid Homo sapiens - PTPB1 0.01623 3,16-dioxo-olean-12(13),17(18)-diene Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.00233 3-(2,2'-dimethyl-carboxypropanoyloxy)-oleanolic acid Homo sapiens - 0.00272 3-(2-carboxy-benzyloxy)-oleanolic acid Homo sapiens - 0.00458 3-(2-carboxybenzoyloxy)-oleanolic acid Homo sapiens - 0.008 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide Homo sapiens pH and temperature not specified in the publication 0.00062 3-(3-carboxy-benzyloxy)-oleanolic acid Homo sapiens - 0.00015 3-(4-carboxy-benzyloxy)-28-[4-butyric((s)-1-carboxyphenylethyl)-amide]-DELTA12-oleanene Homo sapiens - 0.00054 3-(4-carboxy-benzyloxy)-oleanolic acid Homo sapiens - 0.3 3-([2-chloro-6-methoxy-4-[(E)-(3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]phenoxy]methyl)benzoic acid Homo sapiens above, pH 7.0, 25C 0.00267 3-benzyloxy-oleanolic acid Homo sapiens - 0.002 3-bromo-4-[(2,3-dibromo-4,5-dihydroxyphenyl)methyl]-5-(propoxymethyl)benzene-1,2-diol Homo sapiens pH and temperature not specified in the publication 0.0015 3-bromo-4-[(2,3-dibromo-4,5-dihydroxyphenyl)methyl]-5-[(2-methylpropoxy)methyl]benzene-1,2-diol Homo sapiens pH and temperature not specified in the publication 0.00063 3-bromo-4-[(2,3-dibromo-4,5-dihydroxyphenyl)methyl]-5-[[(propan-2-yl)oxy]methyl]benzene-1,2-diol Homo sapiens pH and temperature not specified in the publication 0.00686 3-butyl-7-(2,4-dihydroxy-6-pentylphenoxy)-3,5-dimethoxy-2-benzofuran-1(3H)-one Homo sapiens - - 0.00597 3-carboxypropanoyloxy-oleanolic acid Homo sapiens - 0.00261 3-dehydroxy-oleanolic acid Homo sapiens - 0.00289 3-ethyl oxalyl-oleanolic acid Homo sapiens - 0.0635 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 3-acetyl-2,4-dihydroxy-6-methylbenzoate Homo sapiens - - 0.017 3-hydroxy-4-(methoxycarbonyl)-5-methylphenyl 4-(beta-D-galactopyranosyloxy)-2-hydroxy-6-pentadecylbenzoate Homo sapiens - - 0.00285 3-methylene-oleanolic acid Homo sapiens - 0.00286 3-oxalyl-oleanolic acid Homo sapiens - 0.00532 3-oxo-oleanolic acid Homo sapiens - 0.00248 3-[(1-butyl-1,6-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-4-yl)oxy]-4,6-dihydroxy-2-pentylbenzoic acid Homo sapiens - - 0.0119 - 0.1566 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide 0.0044 - 0.0409 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide 0.3 3-[(E)-(3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]benzoic acid Homo sapiens above, pH 7.0, 25C 0.0083 3-[2,5-dimethyl-3-[(3-oxo-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl)methyl]-1H-pyrrol-1-yl]benzoic acid Homo sapiens pH 7.0, 25C 0.0329 3-[3-(2,4-dichlorophenyl)propanoyl]-2-hydroxycyclohepta-2,4,6-trien-1-one Homo sapiens pH 7.0, 25C 0.0045 - 0.0371 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid 0.0077 3alpha-cinnamoyloxypterokaurene L3 Homo sapiens pH 6.0, 37C 0.00505 3alpha-oleanolic acid Homo sapiens - 0.00394 3beta,16a,17-trihydroxy-olean-12-ene Homo sapiens - in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37C 0.05 3beta-acetoxy-17beta-hydroxy-28-norolean-12-ene Homo sapiens - IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.044 3beta-acetoxy-28-hydroxyolean-12-ene Homo sapiens - in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.0078 3beta-acetoxyolean-12-en-28-acid Homo sapiens - in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.0093 3beta-acetoxyolean-12-en-28-aldehyde Homo sapiens - in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.0052 3beta-hydroxyolean-12-en-28-oic acid Homo sapiens - in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.00119 4'-[(2-butyl-1-benzofuran-3-yl)methyl]biphenyl-4-ol Homo sapiens pH 7.0, 37C, PTP-B3 0.00108 4'-[2-(4-hydroxybutyl)-1-benzofuran-3-yl]biphenyl-4-ol Homo sapiens pH 7.0, 37C, PTP-B2 0.00573 4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid Homo sapiens - 0.01 4-(((5Z)-2-(4-fluorophenylimino)-4-oxo-5-[(3-phenoxyphenyl)methylidene]thiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0042 4-(((5Z)-2-(4-fluorophenylimino)-4-oxo-5-[(3-phenylmethoxyphenyl)methylidene]thiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0051 4-(((5Z)-2-(4-fluorophenylimino)-4-oxo-5-[(4-phenoxyphenyl)methylidene]thiazolidin-3-yl) methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0019 4-(((5Z)-2-(4-fluorophenylimino)-4-oxo-5-[(4-phenylmethoxyphenyl)methylidene]thiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0071 4-(((5Z)-4-oxo-5-[(3-phenoxyphenyl)methylidene]-2-thioxothiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0057 4-(((5Z)-4-oxo-5-[(3-phenylmethoxyphenyl)methylidene]-2-thioxothiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0106 4-(((5Z)-4-oxo-5-[(4-phenoxyphenyl)methylidene]-2-thioxothiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.005 4-(((5Z)-4-oxo-5-[(4-phenylmethoxyphenyl)methylidene]-2-thioxothiazolidin-3-yl)methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.02 4-(3-(dibenzylamino)phenyl)-2,4-dioxobutanoic acid Homo sapiens - in 50 mM MOPS, pH 6.5, at 30C 0.2732 4-(5-bromo-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoic acid Homo sapiens pH 7.0, 25C 0.00059 4-(beta-D-galactopyranosyloxy)-2-hydroxy-6-pentadecylbenzoic acid Homo sapiens - - 0.0109 4-([(2E,5Z)-2-[(4-methoxyphenyl)imino]-4-oxo-5-[(3-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0025 4-([(2E,5Z)-2-[(4-methoxyphenyl)imino]-4-oxo-5-[(4-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0104 4-([(2E,5Z)-2-[(4-tert-butylphenyl)imino]-4-oxo-5-[(3-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0022 4-([(2E,5Z)-2-[(4-tert-butylphenyl)imino]-4-oxo-5-[(4-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0051 4-([(2E,5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0056 4-([(2E,5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-2-[(4-tert-butylphenyl)imino]-4-oxo-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.003 4-([(2E,5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0014 4-([(2E,5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-2-[(4-tert-butylphenyl)imino]-4-oxo-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.018 4-([(5Z)-2,4-dioxo-5-[(3-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0028 4-([(5Z)-2,4-dioxo-5-[(4-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0145 4-([(5Z)-2-(4-fluorophenylimino)-4-oxo-5-([3-(2-phenylethoxy)phenyl]methylidene)thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0015 4-([(5Z)-2-(4-fluorophenylimino)-4-oxo-5-([4-(2-phenylethoxy)phenyl]methylidene)thiazolidin-3-yl]methyl)benzoic acid Homo sapiens pH 7.0, 37C 0.0019 4-([(5Z)-4-oxo-5-[[3-(2-phenylethoxy)phenyl]methylidene)-2-thioxothiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0035 4-([(5Z)-4-oxo-5-[[4-(2-phenylethoxy)phenyl]methylidene)-2-thioxothiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0796 4-methoxy-3-(5-methoxy-1-benzofuran-6-yl)-5-(4-methoxyphenyl)isoxazole Homo sapiens - 0.0804 4-methoxy-3-(5-methoxy-1-benzofuran-6-yl)-5-phenylisoxazole Homo sapiens - 0.005 4-oxo-8-(phenylsulfanyl)-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid Homo sapiens - 0.0173 4-[(1E)-3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-5-methoxy-2-(2-methylbut-3-en-2-yl)phenyl acetate Homo sapiens - pH 6.0, 37C 0.00022 4-[(2,4-dihydroxy-6-pentadecylbenzoyl)oxy]-2-hydroxy-6-methylbenzoic acid Homo sapiens - - 0.00051 4-[(2,4-dihydroxy-6-propylbenzoyl)oxy]-2-hydroxy-6-propylbenzoic acid Homo sapiens pH and temperature not specified in the publication 0.0292 4-[(2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate Homo sapiens - pH 6.0, 37C 0.05 4-[(2E)-3-[4-(acetyloxy)-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate Homo sapiens - above, pH 6.0, 37C 0.0192 4-[(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate Homo sapiens - pH 6.0, 37C 0.3 4-[2-[(5-chloro-1,3-benzoxazol-2-yl)sulfanyl]acetamido]benzoic acid Homo sapiens above, pH 7.0, 25C 0.0045 - 0.0277 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid 0.0019 4-[[(2E,5Z)-4-oxo-5-[(3-phenoxyphenyl)methylidene]-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0011 4-[[(2E,5Z)-4-oxo-5-[(4-phenoxyphenyl)methylidene]-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0046 4-[[(2E,5Z)-4-oxo-5-[[3-(2-phenylethoxy)phenyl]methylidene]-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0015 4-[[(2E,5Z)-4-oxo-5-[[4-(2-phenylethoxy)phenyl]methylidene]-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0038 4-[[(2E,5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0011 4-[[(2E,5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0095 4-[[(5Z)-2,4-dioxo-5-[[3-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0026 4-[[(5Z)-2,4-dioxo-5-[[4-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0011 4-[[(5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.0016 4-[[(5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acid Homo sapiens pH 7.0, 37C 0.00184 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzyl)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.0021 5-(4-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxyphenoxy)benzyl)thiazolidine-2,4-dione Homo sapiens pH and temperature not specified in the publication 0.0075 5-chloro-N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-1-methyl-2-(methylthio)-1H-benz-imidazole-6-carboxamide Homo sapiens pH 7.0, 37C 0.0194 5-methoxy-4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-2-(2-methylbut-3-en-2-yl)phenyl acetate Homo sapiens - pH 6.0, 37C 0.0011 - 0.003 6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0003 6-chloro-7-(2,3-dihydro-1H-inden-1-ylamino)quinoline-5,8-dione Homo sapiens - 0.00021 6-chloro-7-[(2-morpholin-4-ylethyl)amino]quinoline-5,8-dione Homo sapiens - 0.0086 - 0.0172 6-hydroxy-2-(4-hydroxybenzyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0046 6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid Homo sapiens - - 0.3 6-oxo-6H-cyclohepta[b]furan-5,7-dicarboxylic acid Homo sapiens above, pH 7.0, 25C 0.003 7-(2-((1H-imidazol-2-yl)thio)ethoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0016 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.004 7-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 7-(2-(4-nitro-1H-imidazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0079 7-(2-(5-methyl-1H-tetrazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.007 7-(3-(4-nitro-1H-imidazol-1-yl)propoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0039 7-(4-((1H-imidazol-2-yl)thio)butoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0036 7-(4-(1H-1,2,4-triazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0069 7-(4-(2-methyl-5-nitro-1H-imidazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0151 7-(4-(5-methyl-1H-tetrazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.00082 7-chloro-6-[(2-morpholin-4-ylethyl)amino]quinoline-5,8-dione Homo sapiens - 0.001 7-hydroxy-2-(1-(4-methoxybenzyl)-1H-imidazol-4-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0031 7-hydroxy-2-(1-(4-methoxybenzyl)-1H-imidazol-5-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.006 7-hydroxy-2-(1-pentyl-1H-imidazol-2-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0063 7-hydroxy-2-(1-pentyl-1H-imidazol-4-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.015 7-hydroxy-2-(1-pentyl-1H-imidazol-5-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0098 7-hydroxy-2-(1-propyl-1H-imidazol-2-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.01 7-hydroxy-2-(1-propyl-1H-imidazol-4-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.005 7-hydroxy-2-(1-propyl-1H-imidazol-5-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0112 7-hydroxy-2-(1H-imidazol-2-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.01 7-hydroxy-2-(1H-imidazol-4-yl)-4H-chromen-4-one Homo sapiens pH 7.2, 37C 0.0074 - 0.0124 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0062 - 0.0268 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.001 - 0.0022 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0082 - 0.0184 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.05 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one Homo sapiens - above, pH 6.0, 37C 0.0065 - 0.0173 7-hydroxy-2-(4-hydroxyphenylethyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0053 - 0.0175 7-hydroxy-2-(4-hydroxyphenylmethyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 0.0012 7-hydroxy-2-[1-[(4-methoxyphenyl)methyl]-1H-imidazol-2-yl]-4H-1-benzopyran-4-one Homo sapiens pH 7.2, 37C 0.00087 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid Homo sapiens - - 0.00019 aquastatin A Homo sapiens - - 0.0081 benzyl oleanolic acid amide Homo sapiens - 0.00861 benzyl oleanolic acid ester Homo sapiens - 0.0013 CinnGel 2ME Homo sapiens - - 0.012 ent-3beta-angeloyloxykaur-16-en-19-oic acid Homo sapiens pH 6.0, 37C 0.012 ent-3beta-tigloyloxykaur-16-en-19-oic acid Homo sapiens pH 6.0, 37C 0.01916 ethyl (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-1,2,3,3a,3b,4,6,6a,7,9a,10,10a,10b,11,12,12a-hexadecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]pentanoate Homo sapiens - pH and temperature not specified in the publication 0.04 ethyl (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-8-amino-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoate Homo sapiens - IC50 above 0.04 mM, pH and temperature not specified in the publication 0.0113 - 0.1 ethyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00479 - 0.03576 ethyl (4R)-4-[(E)-2-(4-chlorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 ethyl (4R)-4-[(E)-2-(4-fluorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate Homo sapiens above, pH and temperature not specified in the publication 0.00238 - 0.04037 ethyl (4R)-4-[(E)-2-(4-methoxyphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00749 - 0.1 ethyl (4R)-4-[(E)-2-(4-methylphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 - 0.1 ethyl (4R)-4-[(E)-2-(4-nitrophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 ethyl (4R)-4-[(E)-2-phenylethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate Homo sapiens above, pH and temperature not specified in the publication 0.01035 - 0.1 ethyl (4R)-6-(propan-2-yl)-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00446 ethyl 2-(2-bromophenyl)-4-[(4-methoxyphenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01041 ethyl 2-(2-bromophenyl)-4-[(4-methylphenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01079 ethyl 2-(2-bromophenyl)-4-[(4-nitrophenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.00803 ethyl 2-(4-bromophenyl)-4-[(4-methoxyphenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.06475 ethyl 2-(4-bromophenyl)-4-[(4-nitrophenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.00969 ethyl 2-(4-fluorophenyl)-4-[(4-methylphenoxy)methyl]-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01073 ethyl 4-[(4-chlorophenoxy)methyl]-2-(3-phenoxyphenyl)-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01158 ethyl 4-[(4-methoxyphenoxy)methyl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01205 ethyl 4-[(4-methylphenoxy)methyl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.01122 ethyl 4-[(4-methylphenoxy)methyl]-2-(3-phenoxyphenyl)-1,3-thiazole-5-carboxylate Homo sapiens pH not specified in the publication, 37C 0.0138 glycyrrhetic acid Homo sapiens - in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.288 hesperetin Homo sapiens pH 6.0, 37C 0.0371 hesperetin 5-O-glucoside Homo sapiens pH 6.0, 37C - 0.3 hesperetin 7-O-glucoside Homo sapiens above, pH 6.0, 37C 0.0582 hesperidin Homo sapiens pH 6.0, 37C 0.0191 licochalcone A Homo sapiens pH 6.0, 37C 0.004 licochalcone E Homo sapiens pH 6.0, 37C 0.01274 - 0.02045 lithocholic acid 0.0137 lupenone Homo sapiens - pH 6.0, 37C 0.0056 lupeol Homo sapiens - pH 6.0, 37C 0.01947 maslinic acid Homo sapiens - TCPTP 0.00904 methyl (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-8-amino-6,6,10a,12a-tetramethyl-2,3,3a,3b,4,6,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[2,3-d][1,3]thiazol-1-yl]pentanoate Homo sapiens - pH and temperature not specified in the publication 0.02822 methyl (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinoxalin-1-yl]pentanoate Homo sapiens - pH and temperature not specified in the publication 0.00628 - 0.1 methyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.01099 - 0.03603 methyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-tert-butyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00712 - 0.1 methyl (4R)-4-[(E)-2-(4-chlorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00333 - 0.1 methyl (4R)-4-[(E)-2-(4-fluorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 methyl (4R)-4-[(E)-2-(4-methoxyphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate Homo sapiens above, pH and temperature not specified in the publication 0.01855 - 0.1 methyl (4R)-4-[(E)-2-phenylethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00549 - 0.1 methyl (4R)-6-(propan-2-yl)-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00631 - 0.1 methyl (4R)-6-tert-butyl-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.00665 - 0.05481 methyl (4R)-6-tert-butyl-4-[(E)-2-(4-chlorophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 methyl (4R)-6-tert-butyl-4-[(E)-2-(4-fluorophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate Homo sapiens above, pH and temperature not specified in the publication 0.00503 - 0.1 methyl (4R)-6-tert-butyl-4-[(E)-2-(4-methoxyphenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.0163 - 0.1 methyl (4R)-6-tert-butyl-4-[(E)-2-(4-methylphenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.01138 - 0.1 methyl (4R)-6-tert-butyl-4-[(E)-2-(4-nitrophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate 0.05 methyl (4R)-6-tert-butyl-4-[(E)-2-phenylethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate Homo sapiens above, pH and temperature not specified in the publication 0.2 methyl 2,4-dihydroxy-6-methylbenzoate Homo sapiens - above 0.00742 methyl 3,8-dimethoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate Homo sapiens - - 0.2 methyl 3-formyl-2,4-dihydroxy-6-methylbenzoate Homo sapiens - above 0.01321 methyl 4,4-dimethyl-3-oxochol-5-en-24-oate Homo sapiens - pH and temperature not specified in the publication 0.00037 methyl 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylate Homo sapiens - 0.00302 methyl 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate Homo sapiens - - 0.0092 methyl oleanolic acid amide Homo sapiens - 0.00444 methyl oleanolic acid ester Homo sapiens - 0.0018 N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide) Homo sapiens - - 0.00089 N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-methylphenyl)acetamide Homo sapiens - 0.00062 N-(3-[(4-chlorophenyl)sulfanyl]-1,4-dioxo-1,4-dihydronaphthalen-2-yl)acetamide Homo sapiens - 0.01 N-([4-[difluoro(phosphono)methyl]phenyl]acetyl)-a-aspartyl-4-[difluoro(phosphono)methyl]phenylalaninamide Homo sapiens - - 0.0039 N-[5-(dimethylamino)-2-hydroxy-3-methoxybenzyl]-N-methyl-2-(4-nitrophenyl)ethanaminium Homo sapiens - 0.0313 N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-2,2,2-trifluoroacetamide Homo sapiens pH 7.0, 37C 0.0025 NAT6-297775 Homo sapiens - Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25C 0.1436 neohesperidin Homo sapiens pH 6.0, 37C 0.0003 NSC-87877 Homo sapiens - Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25C 0.00204 - 0.0076 oleanolic acid 0.00476 oleanolic acid amide Homo sapiens - 0.02 oleanolic alcohol Homo sapiens IC50 above 0.02 mM 0.0035 oleanonic acid Homo sapiens - - 0.0039 pomolic acid Homo sapiens - - 0.0011 rilobolide-6-O-methacrylate Homo sapiens pH 6.0, 37C 0.0041 - 0.0045 RK-682 0.0109 rotungenic acid Homo sapiens - - 0.002 small t antigen Homo sapiens - using p-nitrophenyl phosphate as a substrate - 0.0562 Sodium vanadate Homo sapiens - 0.0188 spathodic acid Homo sapiens - - 0.05 stigmasterol Homo sapiens - IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.05 taraxerol Homo sapiens - IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37C 0.022 tetrachyrin Homo sapiens pH 6.0, 37C 0.0025 - 0.00965 ursolic acid 0.0156 uvaol Homo sapiens - - 0.1 ZINC39276654 Homo sapiens above, pH not specified in the publication, 37C - 0.0158 [2-bromo-4-[(E)-(7,8-dimethyl-3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]-6-ethoxyphenoxy]acetic acid Homo sapiens pH 7.0, 25C 0.000005 [7-[4-[2-(1H-benzotriazol-1-yl)-2-[4-[difluoro(phosphono)methyl]phenyl]-3-phenylpropyl]phenyl]-2-(1-methoxy-3-methylbutyl)quinolin-8-yl]phosphonic acid Homo sapiens pH and temperature not specified in the publication 0.3 [[1-(4-chlorophenyl)-2-methyl-1H-indol-5-yl]oxy]acetic acid Homo sapiens above, pH 7.0, 25C 0.00219 [[4'-(2-butyl-1-benzofuran-3-yl)biphenyl-4-yl]oxy]acetic acid Homo sapiens pH 7.0, 37C, PTP-B4 106 - substrate 4-nitrophenyl phosphate 15700 purified recombinant catalytic domain, pH 7.0, 37C, substrate 4-nitrophenyl phosphate 19.7 - cytoplasmic enzyme 42.7 - membrane-bound enzyme 6.6 - substrate bovine serum albumin, calculated as micromol phosphate released per min 5 - 5.5 - substrate 4-nitrophenyl phosphate, subtype 1A 5 - 5.6 - substrates 4-nitrophenyl phosphate and ENDpYINASL, enzymes PTP2C and DELTASH2-PTP2C 5.5 - 6 - substrate 4-nitrophenyl phosphate, subtype 1B 5.6 - substrate 4-nitrophenyl phosphate 6.5 - 7.5 - substrates lysozyme and myelin basic protein, enzymes PTP2C and DELTASH2-PTP2C 4 - 4.5 - islet cell antigen-related PTP 4 - 9 activity range of the recombinant catalytic enzyme domain, profile overview 5 - 6.7 - less than half-maximal activity above and below 5 - 9 - pH 5: 13% of maximal activity, pH 9: 50% of maximum activity 7 - 30-40% of the activity at optimal pH-value additional information - - 26 - 42 over 50% of maximal activity within this range, recombinant catalytic enzyme domain, profile overview - UniProt brenda - human glioblastoma cell line brenda - - brenda - brenda - - brenda - - brenda - - brenda - - brenda primary mediastinal B cell lymphoma cell, PMBCL brenda - - brenda PTPN5 brenda - brenda - breast carcinoma, high expression brenda - brenda - brenda PTPRR brenda - - brenda - - brenda - brenda - - brenda - - brenda - - brenda - brenda - brenda - increased expression in umbilical vascular endothelial cells and microvascular endothelial cells upon exposure to phorbol 12-myristate 13-acetate brenda - - brenda - lung brenda - - brenda - - brenda - HCL cells display increased expression of the phosphatases SPH-1 and SPH-2 as compared with normal B-lymphocytes, HCL cells require protein-tyrosine phosphatase activity for preservation of their viability brenda - - brenda - - brenda - - brenda - - brenda - - brenda - brenda - brenda - - brenda - LMW-PTP is the predominant tyrosine phosphatase expressed in lens brenda - - brenda - - brenda - - brenda PTPN7 brenda - brenda - brenda - a melphalan-sensitive myeloma cell line, from the peripheral blood cells of a patient with IgA myeloma, secretes lambda L chain, is negative for the presence of the EBV genome, and expresses leukocyte antigen DR, plasma cell Ag-1, and T9 and T10 antigens brenda - brenda - - brenda - - brenda - brenda - - brenda - receptor-type protein tyrosine phosphatase CD148 brenda - brenda - brenda - - brenda - - brenda - - brenda - - brenda - - brenda - a head and neck squamous cell carcinoma cell line brenda - neuroblastoma cell, high expression of enzyme brenda - - brenda - - brenda PTPN7 brenda PTPN5 brenda - - brenda - - brenda - - brenda PTPN7 brenda - - brenda - brenda - - brenda - - brenda - brenda receptor protein tyrosine phosphatases (PTPRs) are a family of cell surface receptor proteins brenda - 50% membrane-bound, 30% bound to the cytoskeleton, 20% cytosolic brenda - isolation from cell lysate - brenda Highest Expressing Human Cell Lines Cell Line Links Gene Links PTPRM_HUMAN 1452 1 163682 Swiss-Prot other Location (Reliability: 1) 116000 - x * 116000, enzyme from A172 cells, SDS-PAGE 16900 - x * 16900, SDS-PAGE 185000 - x * 185000, receptor tyrosine phosphatase, SDS-PAGE 37000 - non-specific proteolytic cleavage of PTP1B yields a band migrating at approximately 37000 Da, SDS-PAGE 38000 - 1 * 38000, SDS-PAGE 38500 - 1 * 38500, deduced from gene sequence 45000 - 1 * 45000, SHPTP1 catalytic domain, SDS-PAGE 46000 - truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE 48000 - truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE 53000 - SHPTP1, catalytic domain, gel filtration 55209 - 55943 recombinant monomeric thioredoxin-fused enzyme, mass spectrometry 63000 - 1 * 63000, SHPTP1, full length enzyme, SDS-PAGE 64816 recombinant monomeric thioredoxin-fused enzyme, gel filtration 72000 - SHPTP1, full length enzyme, gel filtration 76770 - splicing variant SV3 of LMW-PTP, calculation from nucleotide sequence 77000 - x * 77000, splicing variant SV3 of LMW-PTP, SDS-PAGE glycoprotein - N-linked glycosylation active site mutant C215S in complex with substrates bis-(para-phosphophenyl) methane and 4-nitrophenyl phosphate both wild-type PTP-1B and its mutant L119V - C-terminal truncated form, ligand-free, in auto-inhibited conformation - catalytic domain and C455S mutant of catalytic domain, in complex with peptide substrates catalytically active, monomeric D1 domain - cytoplasmic D1D2 segment of CD45, in native and phosphotyrosyl peptide-bound form - enzyme in oxovanadium-complexes, termed [VIVO(SAA)(2,2'-bipyridine)]0.25bpy and [VIVO(SAA)(1,10-phenanthroline)]0.33H2O, overview - hanging drop vapour diffusion method with 0.05 M Bis-Tris (pH 7.0), 24% (v/v) PEG3350, 0.1 M lithium sulfate, 0.2 M magnesium sulfate and 10 mM dithiothreitol hanging drop vapour diffusion method with 0.1 M HEPES-NaOH pH 7.5, 10% 2-propanol, 10 mM magnesium acetate and 20% (w/v) PEG 4000 at 18C - hanging drop vapour diffusion method with 0.2 M MgCl2, 4.5% PEG 10000 (w/v) and 0.1 M HEPES (pH 7.5) - hanging drop vapour diffusion method with 1.5 M sodium chloride, 10% (v/v) ethanol, and 10 mM dithiothreitol - hanging drop vapour diffusion method with 18-22% PEG 8000, 200 mM MgCl2, 100 mM Tris-HCl pH 8.0, and 1% (v/v) beta-mercaptoethanol in complex with inhibitors 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N,N-dimethyl-1-benzofuran-6-sulfonamide, 3-((3,5-dibromo-4-hydroxyphenyl)carbonyl)-2-ethyl-N-(4-(1,3-thiazol-2-ylsulfamoyl)phenyl)-1-benzofuran-6-sulfonamide and 3-((3,5-dibromo-4-hydroxyphenyl)carbonyl)-2-ethyl-N-(4-sulfamoylphenyl)-1-benzofuran-6-sulfonamide in complex with monophosphorylated and dually phosphorylated Erk2 peptides, sitting drop vapour diffusion method, in 0.2 M ammonium tartrate, pH 6.6, and 20% (w/v) PEG 3350 or and 1.0 M lithium chloride, 0.1 M citrate, pH 5.0, and 20% (w/v) PEG 6000 molecular dynamics simulations of the crystal structure of the enzyme catalytic domain and of mutant R47V/D48N/M258C/G259Q, both in complex with substrate 4-nitrophenyl phosphate and as cysteine-phosphor complex phosphotyrosine phosphatase 1B - PTP1B and PTP1B mutant F182H in complex with inhibitors purified recombinant detagged enzyme, hanging drop vapor diffusion method, mixing of 0.0018 ml of protein solution, containing 18 mg/ml protein in 20 mM HEPES-NaOH, pH 7.0, 0.2 M NaCl, 5 mM MgCl2, 20 mM DTT, and 5% glycerol, with an equal volume of reservoir solution containing 0.1 M bis-Tris, pH 6.0, and 2.4 M NaCl, 18C, 3 days, X-ray diffraction structure determination and analysis at 2.4 A resolution purified recombinant enzyme mutants D811A/C842S, D811E/C842S, D811A/H812F/C842S/M883G, Y676I, and D811E in complex with substrate Eps15846-854, and with mutant Eps15846-854 P450V, X-ray diffraction structure determination and analysis at 1.26-1.72 A resolution purified recombinant wild-type and mutant isolated membrane-proximal D1 and distal D2 domains of protein tyrosine phosphatase epsilon, and PTPepsilon (A455N/V457Y/E597D) D2 domain mutant, hanging drop vapour diffusion method, for PTPepsilon D1 domain mixing of 0.002 ml of 13.9 mg/ml protein solution with 0.002 ml of reservoir solution containing 0.1 M Tris-HCl, pH 8.5, 0.2 M sodium chloride, and 22% w/v PEG 3350, for wild-type PTPepsilon D2 domain mixing of 0.001 ml of 5.0 mg/ml protein solution with 0.003 ml of reservoir solution containing 0.1 M bicine/trizma base, pH 8.5, 0.03 mM diethylene glycol, 0.03 M triethylene glycol, 0.03 M tetraethylene glycol, 0.03 M pentaethylene glycol, 10% w/v PEG 4000, and 20% v/v glycerol, and for mutant A455N/V457Y/E597D PTPepsilon D2 domain mixing of 0.002 ml of 9.0 mg/ml protein solution with 0.002 ml of reservoir solution containing 0.1 M imidazole, pH 8.0, 0.2 M calcium acetate hydrate, 20% w/v PEG 1000, in all cases equilibration against 0.5 ml reservoir solution, X-ray diffraction structure determination and analysis at 1.67-2.27 A resolution recombinant N-terminally His-tagged inactive enzyme mutant C227S, im complex with the consensus peptide substrate or SKAP-HOM, a bona fide Lyp substrate, 3-5 days, X-ray diffraction structure determmination and analysis at 2.5 A and 2.9 A resolution, respectively, molecular replacement - SHP-1, in the open, active conformation, hanging-drop vapor diffusion, 4C, mixing of 0.0025 ml of protein solution, containing 3.6 mg/ml protein in 25 mM Tris-HCl, pH 7.5, 0-1 M NaCl,2 mM 2-mercaptoethanol, 1 mM EDTA, with 0.0025 ml of reservoir solution, containing 1.8 M ammonium sulfate, 0.1 M glycine, 0.1 M Tris-HCl, pH 7.0, and additon of 0.5 ml 14 mM deoxy Big Chap detergent, X-ray diffraction crystal structure determination and analysis at 3.1 A resolution, molecular replacement - sitting drop vapour diffusion method using 25% PEG-3350, 0.2 M LiSO4, and 100 mM Bis-Tris, pH 5.5, or 0.15 M malic acid, pH 7.0, 20% PEG-3350 and 2.0 M (NH4)H2PO4, 0.1 M Tris/HCl, pH 8.5 - two transition-state analogues, by sitting drop vapor diffusion method, 4C, mixing of 0.002 ml of protein solution, containing native PTPB1, peptide DADEYL, and Na3VO4 in 10 mM Tris, pH 7.5, 25 mM NaCl, 0.2 mM EDTA, and 3 mM DTT, with 0.0005 ml of sucrose 30% v/v solution, and 0.003 ml of precipitant solution, containing 0.1 M HEPES, pH 7.5, 0.2 M magnesium acetate and 15-17% PEG 8000, 3 days, X-ray diffraction structure determination and analysis at 2.25-2.3 A resolution wild type and C215D mutant, both are structurally identical 416AA - of PTPalpha, Km-value similar to wild-type, up to 2fold activation by tetrasodium 2-(((2-(3-(((3-(5-((2,5-disulfonatophenyl)carbamoyl)-1H-benzimidazol-2-yl)phenyl)carbamoyl)amino)phenyl)-1H-benzimidazol-5-yl)carbonyl)amino)benzene-1,4-disulfonate 529AA - of PTPalpha, Km-value similar to wild-type, up to 11.6fold activation by tetrasodium 2-(((2-(3-(((3-(5-((2,5-disulfonatophenyl)carbamoyl)-1H-benzimidazol-2-yl)phenyl)carbamoyl)amino)phenyl)-1H-benzimidazol-5-yl)carbonyl)amino)benzene-1,4-disulfonate A122F site-directed mutagenesis, affects inhibition by abietic acid and 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine-3-carboxylic acid A122S site-directed mutagenesis, affects inhibition by abietic acid A189S site-directed mutagenesis, affects inhibition by 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran-6-sulfonic acid-[4-(thiazol-2-ylsulfamyl)phenyl]-amide and 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine-3-carboxylic acid A455N/V457Y/E597D site-directed mutagenesis, the triple mutant of the PTPepsilon D2 domain is constructed to reconstitute the residues of the PTPepsilon D1 catalytic domain that are important for phosphatase activity, resulting in only a slight increase in the phosphatase activity compared with the wild-type D2 protein

Release of infectious Epstein-Barr virus by transformed marmoset leukocytes

The Role of Glutathione in the Body Antioxidant Properties : Glutathione plays a crucial role in combating oxidative stress by neutralizing harmful free radicals

Niacinamide is a form of Vitamin B3, and at 12%, this formula works on oil control, pore refinement, and post-acne marks all at the same time

TABLE 2 Predictive performance of the PBPK models of S-CIT and omeprazole in capturing the ratios (DDI/control) in PK parameters (C max and ) under DDI conditions