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Some studies have shown that CB2 receptor activation with small-dose of exogenous agonist, induces cell proliferation leading to CRC (Lee et al

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As rightly noted, the systemic inflammation index (SII) is a composite measure derived from platelet, neutrophil, and lymphocyte counts, all of which are non-specific markers that can be elevated by a wide range of acute and chronic inflammatory conditions beyond smoking, such as infections, autoimmune diseases, malignancies, and other metabolic syndromes

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