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In the U.S., its 21

Among other factors, the efficient nicotine delivery profile makes smoking the most addictive, reinforcing form of nicotine administration 20,23,24

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As PK parameters, the C max , total plasma nicotine uptake (area under the curve for the testing period of 30 min = AUC 030 min , calculated with the linear trapezoidal rule), and the time of C max (t max ) were calculated

If you experience any unusual changes in mood or behavior while taking either of these drugs, you should stop taking the medicine and call your health care professional right away