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Guideline for Treating Tobacco Use and Dependence

Mental and Physical Impairment Cross-fading can reduce reaction times, impair judgment and decision-making abilities, decrease coordination, and impede motor skills

In less than 30 minutes, however, about half of the nicotine has left the bloodstream, and the smoker starts feeling less alert, more edgy

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Even after accounting for a 25 day delivery window, the per-carton savings are substantial enough that most customers plan one week ahead and never look back

Thus, nicotine-dependent smokers must continue nicotine intake to avoid distressing somatic and affective withdrawal symptoms