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The walls of the airways become thicker, more reactive, and more sensitive to triggering factors

But whereas their work - however brilliant - has a polished, fundamentally orthodox quality, Dylan, at his stunning best, seems to be in touch with another reality

It shows that smoking has a serious impact even when people are younger, Hackshaw said, adding, Treatments for stroke are much better now (fewer die from it straight away), many people who suffer one can have long-lasting consequences and physical disabilities at an age when they are usually expected to be working and physically active/fit.

In the footage, published by Mail Online, the pair are heard joking about a "joint" as they smoke what looks like a rolled-up cigarette in the back of a car in Peru

The research was supported by the Medical Research Council, Wellcome Trust, the European Union Seventh Framework Program and Horizon 2020 programme