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Chen and Kandel (1995) monitored a cohort of adolescents and found that more than half of males and just under half of females were still smoking at ages 34 and 35, whereas 25.3 percent of males and 14.3 percent of females were using marijuana and 18.2 percent of males and 12.7 percent of females were using other illicit drugs at that same age

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Commercial manufacture did not start in earnest until the 1930s

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The key is to figure out what those are and find treatments so users can still experience the upside of cannabis