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From the neuronal perspective, intraepidermal nerve fibers in AD can be subdivided into functionally distinct subsets that mediate histamine-independent itch by responding to external stimuli or by engaging immune cells such as MCs, thereby contributing to both acute and chronic pruritus and shaping neuroimmune interactions in the lesional microenvironment (123)

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This knowledge will help you target the right surfaces and use the right methods rather than wasting time on approaches that dont address the root cause

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that addiction takes over a persons life