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Exclusion criteria We excluded patients with a history of acute coronary syndrome within the previous six months to minimize the risk of confounding by residual ischemia or cardiomyopathy

That difference is part of why weed for tobacco withdrawal can feel helpful, because you are not replacing the same chemical effect

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Nicotine increases the risk of heart disease, stroke, and brain damage

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Collectively, these nicotine-mediated factors result in altered blood homeostasis that consequentially promotes platelet-dependent thrombosis, increases the risk of ischemic stroke, and exacerbates secondary brain injury (Wannamethee et al., 2005