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The number of individuals with PD with high intensity or long duration of smoking was relatively small, which requires careful consideration when interpreting the results

Moreover, the effect of nicotine was abolished by infusion of atractyloside, an inhibitor of adenine nucleotide translocase, suggesting that the nicotine induced-increase of oxygen consumption depends on ADP supply to mitochondria and is related to the changes in mitochondrial respiration state 3

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