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At first, it worked reasonably well, as the Pioneers re-recorded several of their standards (including "Cool Water" and "Tumbling Tumbleweeds") with new arrangements that proved popular, and many fans regard their mid-'40s versions of their classic songs as the best of the many renditions that they recorded

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Several factors increased the amount of thermal degradation products delivered per puff, including repeated puffs within a half hour and increasing the e-cigarette voltage, both of which result in heating the liquid at a higher temperature

Several methods helped the researchers to subsequently map these sites