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Data availability Data is provided within the manuscript

Interestingly, Recent evidence has suggested a linear PINK1-Parkin mitophagy pathway, which places PINK1 as a critical upstream molecule for Parkin recruitment ( Emerging evidence indicates that mitophagy plays a crucial role in the regulation of liver homeostasis ( in vivo and in vitro , which is linked to elevated cell death and aggregated liver injury ( With respect to the regulatory pathways that influence mitochondrial integrity and function, we found that p53 was potently activated in HS-treated hepatocytes

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