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Although IL-18 knockout mice exhibit reduced pulmonary inflammation and emphysema compared to wild-type mice after cigarette smoke [21, 24], pulmonary inflammation occurred independent of NLRP3/caspase-1 axis after four weeks of cigarette smoke exposure [25]

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Moreover, the economic burden of tobacco-related illnesses places a strain on healthcare systems and hampers socio-economic development in many countries

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PMID 12963335