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The CB1 neutral antagonist AM4113 retains the therapeutic efficacy of the inverse agonist rimonabant for nicotine dependence and weight loss with better psychiatric tolerability

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As far as the UK is concerned, Ridgway recommended that authorities review the evidence regarding the effectiveness of plain packaging and also consider governmental revenue losses as a result of the increasing illicit trade, which in the UK is now running at GBP2.8 billion per annum, or around GBP8 million a day, according to HMRC figures. If that happened, it also could throw a lifeline not only at tobacco businesses and associated industries, including marketing and engineering services using highly skilled employees

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