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[6] A 2015 study hypothesized from the data that at high voltage (5.0 V), a user, "vaping at a rate of 3 mL/day, would inhale 14.4 3.3 mg of formaldehyde per day in formaldehyde-releasing agents." [17] The 2015 study used a puffing machine showed that a third-generation e-cigarette turned on to the maximum setting would create levels of formaldehyde between five and 15 times greater than with cigarette smoke

This excess may be due to their having more health problems and health awareness than younger counterparts 31

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The relative importance of genetic and epigenetic alterations in cancer risk was estimated by measuring point mutations and aberrant DNA methylation in normal-appearing tissues of healthy individuals (low risk), individuals exposed to risk factors (intermediate risk), and patients with esophageal or gastric cancers (high risk) [43]