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Tobacco use by adolescents has adverse consequences, such as premature atherosclerosis, diminished lung function, complications in oral health, impulse control difficulties, and reduced physical endurance 4,5

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Any concentration below the limit of detection (LOD) was replaced by an imputed value of LOD/ ( When analyzing smoking time trends, we used logistic regression to estimate the prevalence of smokers in each time period

Fagerstrom KO, Kunze M, Schoberberger R, Breslau N, Hughes JR, Hurt RD, et al: Nicotine dependence versus smoking prevalence: comparisons among countries and categories of smokers