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Perception of bronchoconstriction in smokers with airflow limitation

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This type is often associated with chronic acid reflux (gastroesophageal reflux disease or GERD) and obesity, which can cause changes in the esophageal lining known as Barretts esophagusa precursor to adenocarcinoma

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The nicotine addiction itself can trigger cravings for other addictive substances, complicating the overall recovery effort and increasing the risk of relapse