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These were ex-vivo permeation experiments framed around anti-inflammatory delivery rather than wrinkle outcomes, so they speak to whether the molecule can reach the dermis, not to how much cosmetic change follows but even that limited, mechanism-level demonstration is one the injectable route has no equivalent of for reaching skin specifically

Even at 5x higher doses, sublingual formulations produce 4x lower peak GH response in head-to-head studies

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