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Most prior studies are cross-sectional or based on small to medium samples, limiting the ability to clarify whether smoking contributes to the onset or worsening of depression, or whether depression drives smoking behaviors [23]

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Intensifying competition from both established tobacco companies and new entrants pressures pricing and innovation

The lips can exhibit uneven darkening (hyperpigmentation) and appear blotchy purple, dark brown, or black in color

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Metal's opaque nature ensures that no light reaches the contents, which is crucial for materials sensitive to light degradation