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While researchers need to do more testing to find out exactly why vitamin C offers a protective effect for the lungs, they speculate that it blocks collagen deposits that form around the airways from smoke and nicotine exposure, and/or prevents epigenetic changes from in-utero tobacco exposure

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Almost all of these patients had received treatment with the immunosuppressants azathioprine or 6-mercaptopurine (6MP) concomitantly with a TNF blocker at or prior to diagnosis

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