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3 Also, progression-free survival (PFS) and disease-free interval seemed to be improved for patients with SCLC who quit smoking at diagnosis, but for NSCLC this trend did not hold true in the selected studies

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The parthanatos pathway is classically initiated after PARP-1 overactivation occurs from overwhelming DNA damage

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66 Also, elastin fragments, generated as a result of proteolysis of elastin fibers by neutrophil elastase or the protease MMP-12 during chronic smoke exposure, were shown to promote the recruitment of monocytes