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[2] Growth in the US remained stable until the American Civil War in the 1860s when the primary agricultural workforce shifted from slavery to sharecropping

This may reflect the heightened life and social challenges, expectations, interpersonal alienation, and biological impulses in this demographic group, which may predispose individuals to drug experimentation as a form of self-medication (42)

Supplementary information Supplementary Tables 1 and 2 and Figs

However, women soon began to catch up

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