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5.1 Overview of ferroptosis Ferroptosis is an iron-dependent form of cell death driven by the accumulation of lipid peroxides ( Ferroptosis depends on iron-dependent lipid peroxidation, with its key signaling regulation falling into three broad categories: iron metabolism, glutathione metabolism, and lipid metabolism ( is an essential amino acid antiporter composed of two subunits, SLC7A11 and SLC3A2

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Immunoreactivity for SOD1 has been detected in the nervous system, particularly in motor neurons, small interneurons, astrocytes within the white matter, and ependymal cells lining the central canal 2

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Studies have demonstrated that garlic extracts, particularly the water fraction, can ameliorate allergic airway inflammation by reducing inflammatory cell infiltration and mucus hypersecretion, as well as modulating cytokine profiles to favor anti-inflammatory responses [221]

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