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Specifically, the downregulation of IDH3 suppresses prolyl hydroxylase 2 (PHD2) activity and HIF-1 protein stabilization by reducing the effective level of -KG

Pepsensyal (Acetyl sh-Tetrapeptide-1 derivative): This 99% natural-origin peptide demonstrated in a double-blind, split-face trial with 32 women aged 44-64 years: 11% reduction in crow's feet roughness, 14% reduction in relief amplitude, and 21% increase in dermal echogenicity within 28 days

PMID: 35276062

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And, indeed, as you can see at 4:22 in my video , over the course of a day, significantly fewer chlorogenic acids made it into peoples bloodstreams when they drank their coffee with milk as compared to black