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& Jafar-Nejad, H

(127) published in Cell Host Microbe in 2023 identified two distinct gut microbial pathways involved in PAGln production

Additionally, during illness or infection , the body produces more free radicals

Reference: Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target (2025)

Essential mitigation strategies include fasting morning blood draws, 24-h urine collections to integrate metabolite production over diurnal cycles, dietary adjustment in statistical models, and repeated measurements to capture intra-individual variability