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Teplizumab exerts a potent affinity for the CD3 E chain, thereby impacting CD8 + T cells that participate in the autoimmune attack of pancreatic cells [42]

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[PubMed] He J, Hu B, Shi X, Weidert ER, Lu P, Xu M, Huang M, Kelley EE, Xie W (2013) Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3

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Despite the early marriage, most people in Estancia were happy for them and pitched in to make their wedding a memorable one