is tobacco addictive by itself Tobacco/Nicotine The 101 on e-Cigarettes Infographic

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When receptor proteins on limbic system nerve cells are exposed to high levels of dopamine neurotransmitter molecules for prolonged periods of time, the nerve cells turn down the volume of the signal by lowering the number of receptor proteins on their surfaces

PMID 28961314

In many states, state tobacco excise tax rate remains low, particularly in the states with the highest smoking rates," said co-author Dr