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10 , eaan4886 (2018)

The regulatory pathway for a systemic GHK-Cu therapeutic would require the full spectrum of preclinical toxicology, pharmacokinetics, and clinical trials that have not been conducted

UV spectroscopy: Ultra Violet Spectroscopy FTIR: Fourier Transform Infrared Spectroscopy NMR: Nuclear magnetic resonance XRD: X-ray diffraction DSC: Differential scanning calorimetry T g : Glass transition temperatures TGA: Thermogravimetric analysis SEM: Scanning electron microscopy MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide XTT: 2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide ELISA: Enzyme-linked immunosorbent tests AD: Alzheimer diseases PD: Parkinson diseases BBB: Blood-brain barrier MEM: Memantine DTX: Docetaxel PEI: Polyethyleneimine PAMAM: Poly(amidoamine) PVA: Polyvinyl alcohol PTT: Photothermal therapy CT: Computed Tomography MRI: Magnetic resonance imaging LHRH: Luteinizing Hormone-Releasing Hormone AI: Artificial intelligence ECM: Extracellular matrix FDM: Fused deposition modelling SLA: Stereolithography DLP: Digital light processing BMP-2: Bone Morphogenetic Protein-2 GelMA: Gelatin methacrylate PEEK: Polyether Ether Ketone PEKK: Polyetherketoneketone DLS: Dynamic light scattering FDA: Food and Drug Administration EPR: Enhanced permeation and retention PSMA: Prostate-specific membrane antigen NSCLC: Non-Small Cell Lung Cancer VEGF: Vascular endothelial growth factor DPSC: Di stearoyl phosphocholine PNIPA: Poly(N-isopropylacrylamide) WHO: World health organization PFCNPs: Perfluorocarbon-based polymeric nanoparticles CPT: Camptothecin ML: Machine learning ANN: Artificial neural networks SVM: Support vector machines HTS: High-throughput screening mRNA: Messenger ribonucleic acid RF: Random Forest PCA: Principal Component Analysis CNN: Convolutional Neural Network RNN: Recurrent neural network GAN: Generative Adversarial Networks NLP: Natural Language Processing RL: Reinforcement Learning References Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC

A 98 % glutationu znajdujcego si w przestrzeni midzykomrkowej jest w formie zredukowanej (aktywnej), co oznacza, e tylko taka posta glutationu moe wpywa na utrzymanie odpowiedniego poziomu tej substancji w organizmie

& Pan, J

The regulation of MAMs may represent a key mechanism in these processes