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The gut microbiome project has highlighted that

Depletion of fat-resident T-reg cells prevents age-associated insulin resistance

Potential Benefits (preclinical) Fat metabolism: Animal models report reductions in fat mass while lean muscle is preserved [5] [6]

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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

Thats notable because a month ago, when the same FDA advisory committee met to examine the case of giving boosters broadly, the panelists largely felt that they should be limited to older and at-risk individuals